„Diazepám” változatai közötti eltérés

 

Although not usually fatal when taken alone, a diazepam overdose is considered a medical emergency and generally requires the immediate attention of medical personnel. The [[antidote]] for an overdose of diazepam (or any other benzodiazepine) is [[flumazenil]] (Anexate®). This drug is only used in cases with severe respiratory depression or cardiovascular complications. Because flumazenil is a short-acting drug and the effects of diazepam can last for days, several doses of flumazenil may be necessary. [[Artificial respiration]] and stabilization of cardiovascular functions may also be necessary. Although not routinely indicated, [[activated charcoal]] can be used for decontamination of the stomach following a diazepam overdose. [[Emesis]] is contraindicated. [[Dialysis]] is minimally effective. Hypotension may be treated with [[levarterenol]] or [[metaraminol]].<ref name="Inchem"/><ref name="Barondes1"/><ref name="Drugs.com"/><ref name="RXL.Overdose"/>

 

The oral [[LD50|LD₅₀]] (lethal dose in 50% of the population) of diazepam is 720mg/kg in mice and 1240mg/kg in rats.<ref name="Drugs.com"/> D. J. Greenblatt and colleagues reported in 1978 on two patients who had taken 2000 and 500 mg of diazepam, respectively, went into moderately deep comas, and were discharged within 48 hours without having experienced important complications in spite of having high concentrations of diazepam and its metabolites–desmethyldiazepam, oxazepam, and temazepam–according to samples taken in the hospital and as follow-up.<ref name=Greenblatt_et_al_1978>{{cite journal | last = Greenblatt | first = D. J. | coauthors = E. Woo, M. D. Allen, P. J. Orsulak, and R. I. Shader | date = [[October 20]], [[1978]] | title = Rapid recovery from massive diazepam overdose | journal = Journal of the American Medical Association | volume = 240 | issue = 17 | pages = 1872-4 | id = {{PMID|357765}} }}</ref>

* [http://www.rocheusa.com/products/valium/tabspi.pdf Roche Pharmaceuticals (US) – Valium Product Information]

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* [http://www.amc.edu/patient/ems/ems_medication.htm Albany Medical Center] – "Medication of the month"

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{{Benzodiazepinek}}

{{AntikonvulzívSzerek}}

 

[[Kategória:Benzodiazepinek]]

[[Kategória:Altatók]]

 

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[[bg:Диазепам]]