|
== A tiocianát biokémiája a gyógyászatban ==
A tiocianátról<ref name="pmid17404297">{{cite journal | author = Pedemonte N, Caci E, Sondo E, Caputo A, Rhoden K, Pfeffer U, Di Candia M, Bandettini R, Ravazzolo R, Zegarra-Moran O, Galietta LJ | title = Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels | journal = J. Immunol. | volume = 178 | issue = 8 | pages = 5144–53 | year = 2007 | month = April | pmid = 17404297 | doi = | url = | issn = }}</ref> ismert, hogy fontos része a [[hipotiocianit]] [[laktoperoxidázelaktoperoxidáz]] által történő bioszintézisének .<ref name="pmid17204267">{{cite journal | author = Conner GE, Wijkstrom-Frei C, Randell SH, Fernandez VE, Salathe M | title = The lactoperoxidase system links anion transport to host defense in cystic fibrosis | journal = FEBS Lett. | volume = 581 | issue = 2 | pages = 271–8 | year = 2007 | month = January | pmid = 17204267 | pmc = 1851694 | doi = 10.1016/j.febslet.2006.12.025 | url = | issn = }}</ref><ref name="pmid6340603">{{cite journal | author = White WE, Pruitt KM, Mansson-Rahemtulla B | title = Peroxidase-thiocyanate-peroxide antibacterial system does not damage DNA | journal = Antimicrob. Agents Chemother. | volume = 23 | issue = 2 | pages = 267–72 | year = 1983 | month = February | pmid = 6340603 | pmc = 186035 | doi = | url = | issn = }}</ref><ref name="pmid352945">{{cite journal | author = Thomas EL, Aune TM | title = Lactoperoxidase, peroxide, thiocyanate antimicrobial system: correlation of sulfhydryl oxidation with antimicrobial action | journal = Infect. Immun. | volume = 20 | issue = 2 | pages = 456–63 | year = 1978 | month = May | pmid = 352945 | pmc = 421877 | doi = | url = | issn = }}</ref> Emiatt az emberi testben a tiocianát teljes hiányának<ref name="pmid16934416">{{cite journal | author = Childers M, Eckel G, Himmel A, Caldwell J | title = A new model of cystic fibrosis pathology: lack of transport of glutathione and its thiocyanate conjugates | journal = Med. Hypotheses | volume = 68 | issue = 1 | pages = 101–12 | year = 2007 | pmid = 16934416 | doi = 10.1016/j.mehy.2006.06.020 | url = | issn = }}</ref> vagy csökkent mennyiségének<ref name="pmid18519245">{{cite journal | author = Minarowski Ł, Sands D, Minarowska A, Karwowska A, Sulewska A, Gacko M, Chyczewska E | title = Thiocyanate concentration in saliva of cystic fibrosis patients | journal = Folia Histochem. Cytobiol. | volume = 46 | issue = 2 | pages = 245–6 | year = 2008 | pmid = 18519245 | doi = 10.2478/v10042-008-0037-0 | url = | issn = }}</ref> (például [[cisztás fibrózis]]) nagy jelentősége van az emberi test védelmi rendszerében.<ref name="pmid17082494">{{cite journal | author = Moskwa P, Lorentzen D, Excoffon KJ, Zabner J, McCray PB, Nauseef WM, Dupuy C, Bánfi B | title = A novel host defense system of airways is defective in cystic fibrosis | journal = Am. J. Respir. Crit. Care Med. | volume = 175 | issue = 2 | pages = 174–83 | year = 2007 | month = January | pmid = 17082494 | pmc = 2720149 | doi = 10.1164/rccm.200607-1029OC | url = | issn = }}</ref><ref name="pmid19918082">{{cite journal | author = Xu Y, Szép S, Lu Z | title = The antioxidant role of thiocyanate in the pathogenesis of cystic fibrosis and other inflammation-related diseases | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 106 | issue = 48 | pages = 20515–9 | year = 2009 | month = December | pmid = 19918082 | pmc = 2777967 | doi = 10.1073/pnas.0911412106 | url = | issn = }}</ref>
== Fordítás ==
|
